The CORE technology
Peptide Asparaginyl Ligases (PAL)
- Use of peptide ligases for site-specific conjugation
- A family of enzymes for combinatorial conjugation
- 20,000 x faster reaction than other enzymes
- Minimal footprint on the final product (low impact on antibody activity/tumour penetration)
Various types of applications
Any type of target, any type of Payload
- Antibody Drug Conjugates
- Cytotoxic molecules
- Immuno-stimulant
- Radioelement (18F, 67Ga…)
- Nanobodies conjugation to image tumors for diagnosis and personalized treatment
- Other bioconjugates
- Antibody RNA Conjugates
- Antibody DNA Conjugates
- Enzyme conjugation
- Nanoparticle conjugation
- Nanobodies, Affibody, Bispecific binders